The San Francisco 49ers are coming off a much-needed and well-deserved week off after going 9-4 through the first 13 games of their 2025 campaign, and now they’ll host the Tennessee Titans at Levi’s Stadium in Week 15.
San Francisco has won their last three games, outscoring the Arizona Cardinals, Carolina Panthers and Cleveland Browns 87-39. Robert Saleh’s defense has played especially well in the last two games, surrendering 17 total points to the Panthers and Browns.
Heading into this interconference battle in Week 15, San Francisco has opened as 12.5-point favorites, according to BetMGM. The over/under for the contest is set a 44.5 points, and the 49ers are -1000 ($1000 bet wins $100) on the money line.
Tennessee has been tough to watch this year. They fired head coach Brian Callahan six games into the season after going 4-19 during his tenure. Since then, interim head coach Mike McCoy has led them to a 1-6 record. With the Titans in a three-way tie for the worst record in the league (alongside the New York Giants and Las Vegas Raiders), they may be better off losing out and securing the first overall pick for the second year in a row.
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This article originally appeared on Niners Wire: 49ers open as massive favorites against Titans in Week 15 matchup
Reporting by Mike Masala, Niners Wire / Niners Wire
USA TODAY Network via Reuters Connect
