Sep 28, 2025; Santa Clara, California, USA; San Francisco 49ers center Jake Brendel (64) before the game against the Jacksonville Jaguars at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images
Sep 28, 2025; Santa Clara, California, USA; San Francisco 49ers center Jake Brendel (64) before the game against the Jacksonville Jaguars at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images
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49ers starting offensive lineman ruled out after suffering injury vs. Falcons

The San Francisco 49ers have had some horrendous luck on the injury front this year, and that trend continued in the first half against the Atlanta Falcons on Sunday at Levi’s Stadium.

Down 3-0 in the second quarter, the 49ers had a first-and-10 from Atlanta’s 49-yard line when they gave running back Brian Robinson Jr. the ball. Robinson was tackled behind the line of scrimmage for a one-yard loss, and center Jake Brendel remained down on the field after the play.

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Brendel eventually left the field and went to the medical tent, got checked out and returned to the sideline without his helmet on. San Francisco quickly announced that the center is out for the remainder of the game with a hamstring injury.

A quick decision like that usually isn’t a great sign. Hopefully, it’s not a long-term injury, but in the meantime, Matt Hennessy will serve as the team’s center.

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This article originally appeared on Niners Wire: 49ers starting offensive lineman ruled out after suffering injury vs. Falcons

Reporting by Mike Masala, Niners Wire / Niners Wire

USA TODAY Network via Reuters Connect

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