The Detroit Lions are set to meet the Buffalo Bills in a historic Week 2 primetime matchup on Amazon Prime Video. The two teams revealed their Week 2 date will be played on Thursday, Sept. 17 at 8:15 p.m. ET.
It will be the first game ever played at the Bills’ brand new Highmark Stadium. The last time these two teams met was in a 48-42 thriller that the Bills won at Ford Field on Dec. 15, 2024. It was one of just two regular-season losses for the Lions in 2024 en route to the NFC’s No. 1 seed.
Lions quarterback Jared Goff passed for 494 yards and five touchdowns in their last meeting. Bills quarterback Josh Allen countered with 362 passing yards and four total touchdowns.
Buffalo enters 2026 after a 12-5 season that ended in the AFC divisional round at Denver. The Lions were 9-8 in 2025, missing the playoffs for the first time since 2022.
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This article originally appeared on Lions Wire: Detroit schedule: Lions vs. Bills in Week 2 at Highmark Stadium
Reporting by Josh Helmer, Lions Wire / Lions Wire
USA TODAY Network via Reuters Connect
