Coming off a 15-2 season despite a plethora of injuries, the Lions are viewed as one of the favorites to win the NFC and reach Super Bowl LX. Now that Detroit knows the road ahead with the release of their 2025 schedule, we have a better sense of the path they have to navigate. We also have betting lines already set for every game. We’ll go game-by-game and see how many games Detroit is favored in early and by how much in each game. All lines come via DraftKings.
Week 1 at Green Bay Packers
The Lions are 1.5-point underdog for their season opener at Lambeau Field against the Packers.
Week 2 vs. Chicago Bears
Ben Johnson returns to Detroit as head coach of the Bears with Detroit as an early 4.5-point favorite.
Week 3 at Baltimore Ravens
The Lions are getting 3.5 points for their Week 3 Monday night showdown against the Ravens.
Week 4 vs. Cleveland Browns
As expected, this line is very large with the huge gap in talent between these two teams. The Lions are favored by 10.5.
Week 5 at Cincinnati Bengals
Jared Goff versus Joe Burrow should be a fun battle. The Lions have a 1.5-point favored edge at the moment on the road.
Week 6 at Kansas City Chiefs
Unsurprisingly, the Lions are road dogs against Patrick Mahomes and the Chiefs, but not by much, just three points.
Week 7 vs. Tampa Bay Buccaneers
The Lions only lost two regular-season games in 2024. One of them was in Week 2 against the Buccaneers. The Lions have their chance at revenge on Monday night in Week 7 and are favored by 3.5.
Week 9 vs. Minnesota Vikings
Coming off their bye, the Lions face a Vikings team that pushed them all the way to the final week in the division race last season. Detroit won in Week 18, 31-9. This time, Detroit is favored by 4.5.
Week 10 at Washington Commanders
The Lions get their chance to avenge their playoff loss to the Commanders in Week 10. The early betting outlook is Washington will win the rematch, as Detroit is a 1.5-point underdog.
Week 11 at Philadelphia Eagles
The Lions go from the team that knocked them out of the playoffs to the team that won the Super Bowl. The Lions visit Philadelphia on a Sunday night in Week 11 and are an early 3.5-point underdog.
Week 12 vs. New York Giants
The Lions seemingly get a break following a gauntlet when the Giants come to town in Week 12. Detroit is favored by 8.5.
Week 13 vs. Green Bay Packers
Another year, another Thanksgiving clash between the Lions and Packers. The Packers are favored for Week 1 but the Lions have the early edge for Thanksgiving as a 2.5-point favorite.
Week 14 vs. Dallas Cowboys
The two traditional Thanksgiving hosts meet in Detroit in Week 14. The Cowboys will be coming off a date with Patrick Mahomes and the Chiefs on Thanksgiving. Detroit is favored by six.
Week 15 at Los Angeles Rams
Last season, the Lions opened the season with a Sunday night win against the Rams at home. This year, the Lions take a late-season trip to Los Angeles on America’s Game of the Week on Fox. Jared Goff and the Lions are favored by 1.5.
Week 16 vs. Pittsburgh Steelers
The thought remains the Steelers are still in position to land quarterback Aaron Rodgers. Even if they do, it may not change the current line of Lions -6 too much.
Week 17 at Minnesota Vikings
The Lions get some Christmas cheer this season as they’ll spend the holidays in Minnesota against the Vikings. Detroit is currently favored by 2.5.
Week 18 at Chicago Bears
The rematch with Ben Johnson and the Bears comes in the final week of the season. The Lions are hoping to at least be in contention for the No. 1 seed, if not have it locked up by this point. For now, Detroit is favored by 1.5.
Final tally
The Lions are favored in 12 games and underdogs in five.
This article originally appeared on Lions Wire: Lions betting lines for every game following the 2025 schedule release
Reporting by Billy Riccette, Lions Wire / Lions Wire
USA TODAY Network via Reuters Connect
