Indianapolis Colts defensive tackle DeForest Buckner (99) brings down Denver Broncos quarterback Bo Nix (10) on Sunday, Sept. 14, 2025, during a game at Lucas Oil Stadium in Indianapolis.
Indianapolis Colts defensive tackle DeForest Buckner (99) brings down Denver Broncos quarterback Bo Nix (10) on Sunday, Sept. 14, 2025, during a game at Lucas Oil Stadium in Indianapolis.
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NFL injury report, update: San Francisco 49ers vs Indianapolis Colts for NFL Week 16

The Indianapolis Colts host the San Francisco 49ers on “Monday Night Football” in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games.

The Colts, who are without right tackle Braden Smith (concussion, injured reserve), may be without left tackle Bernhard Raimann (elbow). Cornerback Sauce Gardner (calf) has missed the past two games, and defensive tackle DeForest Buckner (neck) and quarterback Anthony Richardson (eye) are eligible to come off injured reserve.

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San Francisco wide receiver Ricky Pearsall left after its first play from scrimmage with an ankle issue, but he returned and had 6 catches for 96 yards.

Both teams have lost players for the rest of the regular season. For the Colts, quarterback Daniel Jones (Achilles) and cornerback Charvarius Ward (concussion); for the Niners, linebacker Fred Warner (ankle), defensive end Nick Bosa (knee) and wide receiver Brandon Aiyuk (knee).

Colts injuries to watch

T Bernhard Raimann

Left tackle Bernhard Raimann (right elbow) left the game against the Seahawks and did not return.

CB Sauce Gardner

Cornerback Sauce Gardner (calf) left early in the Colts’ Week 13 game against the Houston Texans and has missed two games.

DT DeForest Buckner

Defensive tackle DeForest Buckner (neck) practiced during Week 15 but was not activated off injured reserve. He last played in Week 9.

WR Anthony Gould

Wide receiver/special teamer Anthony Gould (foot) missed Week 15 after suffering an injury in Week 14.

49ers injuries to watch

WR Ricky Pearsall

Wide receiver Ricky Pearsall left after the Niners’ first play from scrimmage with an ankle issue, but he returned and had 6 catches for 96 yards.

DT Jordan Elliott

Defensive tackle Jordan Elliott (knee) was inactive against the Titans.

LB Tatum Bethune

Linebacker Tatum Bethune (ankle) was inactive against the Titans.

LB Nick Martin

Linebacker Nick Martin (concussion) was inactive against the Titans.

DE Sam Okuayinonu

Defensive end Sam Okuayinonu (ankle) was inactive against the Titans.

Colts injured reserve

49ers injured reserve

49ers reserve/non-football injury

Reserve/PUP

Joel A. Erickson and Nathan Brown cover the Colts all season. Get more coverage on IndyStarTV and with the Colts Insider newsletter.

This article originally appeared on Indianapolis Star: NFL injury report, update: San Francisco 49ers vs Indianapolis Colts for NFL Week 16

Reporting by Scott Horner, Indianapolis Star / Indianapolis Star

USA TODAY Network via Reuters Connect

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