Green Bay Packers cornerback Keisean Nixon (25) against the Chicago Bears wide receiver DJ Moore (2) on Sunday, December 7, 2025, at Lambeau Field in Green Bay, Wis. The Packers defeated the Bears 28-21.
Wm. Glasheen USA TODAY NETWORK-Wisconsin
Green Bay Packers cornerback Keisean Nixon (25) against the Chicago Bears wide receiver DJ Moore (2) on Sunday, December 7, 2025, at Lambeau Field in Green Bay, Wis. The Packers defeated the Bears 28-21. Wm. Glasheen USA TODAY NETWORK-Wisconsin
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Bears vs. Packers predictions, picks, odds: Who wins Week 16 NFL game?

The Chicago Bears will battle the Green Bay Packers in Week 16 of the 2025 NFL season, where Chicago is looking to redeem themselves after a loss to Green Bay just two weeks ago.

Once again, the Bears and Packers will be playing for first place in the NFC North and the No. 2 seed in the NFC. This time, Chicago gets to host this must-see game that will be broadcast in prime time for all the football world to see. The Bears’ 28-21 last-minute loss to the Packers left a sour taste in players’ mouths, and now they’re focused on evening the score and recording the biggest win in recent franchise history.

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Can Chicago even the series against Green Bay and put distance between them in the NFC North race? The Bears will look to win their 11th game in the last 13.

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Bears vs. Packers odds, money line, over/under

Bears vs. Packers predictions, picks for Week 16

Alyssa Barbieri

Bears 31, Packers 24: I feel more comfortable about Chicago’s chances in this game after they fell just shy of forcing overtime or beating Green Bay two weeks ago — and that was after an ugly first half where they trailed by 11. The Bears now have the benefit of the home crowd — which will be rocking in the franchise’s biggest game in recent history — an offense that found balance in the run and pass and a defense that remains the league’s best at taking the ball away.

Brendan Sugrue

Bears 27, Packers 21: The Soldier Field crowd is going to be raucous, and the atmosphere will feel like a playoff game. The Bears proved they weren’t going to let their last loss spiral into a losing streak, and they’re refocused on the task at hand. It’s time to show they can be a great team and be in the conversation as a legitimate Super Bowl contender with a win on Saturday.

Mike Pendleton

Bears 34, Packers 24: Having to change their defense on the fly, coming into enemy territory with revenge on the minds of the Bears, this is shaping up to be one of the most entertaining games of the entire NFL season. Chicago knows what to correct offensively, and if they can replicate their hot start from last week, they should be able to pull off the victory at Soldier Field.

Vincent Parise

Bears 24, Packers 20: Ben Johnson’s team failed to get the job done at Lambeau Field in Week 14. Well, here in Week 16 at Soldier Field, it’s time to flip the script. This team has won big games all season long, and now is not the time to fold. Losing wouldn’t make anyone lose trust in what they are building, but it would put a fork in the road for 2025. The Bears have what they need on every unit of the football team, now they need to go out and execute.

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This article originally appeared on Bears Wire: Bears vs. Packers predictions, picks, odds: Who wins Week 16 NFL game?

Reporting by Alyssa Barbieri, Bears Wire / Bears Wire

USA TODAY Network via Reuters Connect

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