The San Francisco 49ers 2025 schedule is out which means it is prediction time!
We pored over the schedule, rest advantages, opponent offseason moves, and compiled what we believe to be the exactly correct way this season will go for San Francisco. There are some good wins, some ugly losses, and a postseason berth at the end of it all.
Despite the fact we’ve put so much thought into this, we recommend the NFL have them play the games just in case:
Week 1 at Seattle Seahawks
Every NFC West game should be tight this season, but we’re expecting a motivated 49ers club to come out firing in Seattle. They’re 4-2 in season openers since 2019, and they’ve won their last two by a combined score of 62-26.
Prediction: Win (1-0)
Week 2 at New Orleans Saints
It feels like a reset year for the Saints. San Francisco should be the more talented team here.
Prediction: Win (2-0)
Week 3 vs. Arizona Cardinals
Not every NFC West game is going to be a win, and an early-season slip up against the Cardinals after back-to-back road games wouldn’t be a huge surprise.
Prediction: Loss (2-1)
Week 4 vs. Jacksonville Jaguars
The Jaguars should be improved from last season 4-13 debacle. They still won’t be good enough to overcome the talent gap between the two clubs.
Prediction: Win (3-1)
Week 5 at Los Angeles Rams (TNF)
This one should be a ton of fun. LA is on track to be good again in 2025. In an evenly-matched game we’ll lean toward the home team on Thursday night.
Prediction: Loss (3-2)
Week 6 at Tampa Bay Buccaneers
The extra rest will be a nice advantage for the 49ers in a tough road game vs. the defending NFC South champs.
Prediction: Win (4-2)
Week 7 vs. Atlanta Falcons (SNF)
Atlanta is a high-variance team going into the year. They might win 10 games. They might win five. Either way this should be a primetime win for San Francisco.
Prediction: Win (5-2)
Week 8 at Houston Texans
A Sunday night game into an early Sunday road game the following week is a tough break for the 49ers. DeMeco Ryans’ group is very good and if CJ Stroud bounces back with a big year the Texans could be one of the favorites to win the AFC.
Prediction: Loss (5-3)
Week 9 at New York Giants
It wouldn’t be a surprise to see the 49ers stay somewhere on the East Coast between their Week 8 and 9 road games. Extra time on the East Coast coming off a tough loss should lead to a dominant 49ers performance.
Prediction: Win (6-3)
Week 10 vs. Los Angeles Rams
The shoe is on the other foot in this rivalry now. After years of 49ers dominance in this head-to-head matchup, LA snags a sweep for the second year in a row.
Prediction: Loss (6-4)
Week 11 at Arizona Cardinals
The 49ers do get some NFC West revenge after losing to the Rams. They head down to Arizona and get a much-needed divisional win to split the season series with the Cardinals.
Prediction: Win (7-4)
Week 12 vs. Carolina Panthers (MNF)
Carolina had a nice turnaround last year, but they’re not ready to beat a potential playoff team on the road in primetime.
Prediction: Win (8-4)
Week 13 at Cleveland Browns
In a vacuum the 49ers should be way better than the Browns. But this will be their 13th game in a row, they’re coming off a Monday night game and they’re flying to Cleveland for a 10:00am Pacific Time start. San Francisco overlooks a not-very-good Browns club and catches an upset loss.
Prediction: Loss (8-5)
Week 14 Bye
Getting to the Bye week at 8-5 would be fine as long as they’re healthy and ready to ramp up for their late-season playoff push.
Week 15 vs. Tennessee Titans
This is a good way to come out of the Bye week for the 49ers. Tennessee, even with No. 1 overall pick Cam Ward under center, should be a very winnable game.
Prediction: Win (9-5)
Week 16 at Indianapolis Colts (MNF)
The Colts are having a quarterback competition between Daniel Jones and Anthony Richardson.
Prediction: Win (10-5)
Week 17 vs. Chicago Bears (SNF)
Chicago should be dramatically improved from last season, and with a divisional game looming, the 49ers slip up against a team they blew out a season ago.
Prediction: Loss (10-6)
Week 18 vs. Seattle Seahawks
With a postseason berth potentially on the line, the 49ers take care of business and complete a season sweep of their Pacific Northwest rivals.
Prediction: Win (11-6)
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This article originally appeared on Niners Wire: Realistic win-loss predictions for the San Francisco 49ers’ 2025 schedule
Reporting by Kyle Madson, Niners Wire / Niners Wire
USA TODAY Network via Reuters Connect
