The San Francisco 49ers start their 2025 campaign on the road, as they take on the Seattle Seahawks at Lumen Field on Sunday afternoon for a Week 1 battle.
Kyle Shanahan’s team was disappointing in 2024, going 6-11 and finishing in fourth place in the division. While they dealt with injuries to key players, they also felt a change was necessary on the coaching staff, so they brought back Robert Saleh to be their defensive coordinator, a move that should make a huge difference.
Seattle had a strong first season under head coach Mike Macdonald in 2024, finishing with a 10-7 record and in second place in the NFC West. Like San Francisco, the Seahawks opted for a change at coordinator, replacing Ryan Grubb with former 49ers passing-game coordinator Klint Kubiak.
Before these two teams meet on Sunday, let’s take a look at a few things that fans should know heading into this one.
Rankings
Points scored per game (2024)
Points allowed per game (2024)
Yards gained per game (2024)
Yards allowed per game (2024)
History
The 49ers and Seahawks have met 54 times in their history, with Seattle winning 31 and San Francisco winning 23. The 49ers have won five of their last six regular-season battles. In Seattle, the 49ers are 11-17 all-time and 11-16 in the regular season.
Injury concerns
The 49ers have listed running back Jordan James (finger) and wide receiver Jordan Watkins (ankle) as doubtful for the contest, while running back Christian McCaffrey (calf) is questionable.
The Seahawks have ruled out wide receivers Jake Bobo (concussion) and Dareke Young (hamstring) as well as linebacker Uchenna Nwosu (knee). Everyone else has been cleared to play.
Big roster changes since their last matchup
San Francisco moved on from Aaron Banks, De’Vondre Campbell, Charvarius Ward, Deebo Samuel, Leonard Floyd, Isaac Yiadom, Jordan Mason, Eric Saubert, Talanoa Hufanga, Taybor Pepper and Jaylon Moore.
They brought in Jason Pinnock, Demarcus Robinson (suspended), Mac Jones, Marquez Valdes-Scantling, Brian Robinson, Luke Farrell, Jon Weeks, Thomas Morstead, Bryce Huff and Skyy Moore in free agency or via trade and took Mykel Williams in the first round of the 2025 NFL draft.
Seattle moved on from Laken Tomlison, Geno Smith, DK Metcalf, Tyler Lockett, Dre’Mont Jones, Noah Fant, Rayshawn Jenkins, Stone Forsythe, Roy Robertson-Harris and Tre Brown.
They brought in Sam Darnold, Cooper Kupp, Eric Saubert and Drew Lock in free agency or via trade and took Grey Zabel in the first round of the 2025 NFL draft.
More 49ers: 49ers’ Christian McCaffrey gives his own injury update for Week 1
This article originally appeared on Niners Wire: 49ers vs. Seahawks: 4 things to know heading into the Week 1 matchup
Reporting by Mike Masala, Niners Wire / Niners Wire
USA TODAY Network via Reuters Connect
