The Buffalo Bills know their schedule and potential journey to a Super Bowl next season and spring practices are underway.
Could the Bills pull off the unlikely? It will take a 17-game slate to get there first and how could that unfold?
Here is Bills Wire’s game-by-game prediction for the 2026 schedule:
Week 1: at Houston Texans, 1 p.m.
It’s Joe Brady’s first game as a head coach. Plus the Bills will want to get revenge for recent Houston losses.
Record: 1-0.
Week 2: vs. Detroit Lions, 8:15 p.m. (TNF).
The first game at the new Highmark Stadium? It has to be a win.
Record: 2-0.
Week 3: vs. Los Angeles Chargers, 1:00 p.m.
The Bills could find themselves in a shootout here. At home, that’s a win.
Record: 3-0.
Week 4: vs. New England Patriots, 1:00 p.m.
After losing the AFC East last season, motivation will be high to beat the Patriots in 2026.
Record: 4-0.
Week 5: at Los Angeles Rams, 8:15 p.m. (MNF).
The Rams are potentially the best team in the NFL. It could be a tough one for the Bills leading to a loss.
Record: 4-1.
Week 6: at Las Vegas Raiders, 4:25 p.m.
The Bills should roll a rebuilding Raiders team if they are a serious contender.
Record: 5-1.
Week 7: Bye week.
Record: 5-1.
Week 8: vs. Baltimore Ravens, 1:00 p.m.
The Bills had a great record post-bye week with Sean McDermott has head coach… but he is gone. This feels bound to happen.
Record: 5-2.
Week 9: at Minnesota Vikings, 8:15 p.m. (MNF).
The Bills should have the upper hand, whether Kyler Murray or J.J. McCarthy is at quarterback.
Record: 6-2.
Week 10: at New York Jets, 1:00 p.m.
The Jets have revamped, but the Bills should still handle business.
Record: 7-2.
Week 11: vs. Miami Dolphins, 1:00 p.m.
The Dolphins are the potential No. 1 overall selection at the 2027 NFL Draft… win.
Record: 8-2.
Week 12: vs. Kansas City Chiefs, 8:20 p.m., (Thanksgiving).
The Bills might lose their post-bye juice without McDermott… but won’t lose their Chiefs motivation.
Record: 9-2.
Week 13: at New England Patriots, 4:25 p.m.
After winning the first Patriots matchup, a season split could be on the cards.
Record: 9-3.
Week 14: at Green Bay Packers, 8:20 p.m. (SNF).
The Bills will be desperate to get back to winning ways.
Record: 10-3.
Week 15: vs. Chicago Bears, 8:20 p.m. (Saturday).
This is a tough one to gauge. But there is always a surprising loss sprinkled in and here we have it.
Record: 10-4.
Week 16: at Denver Broncos, 4:30 p.m. (Christmas).
The revenge factor here will be huge for the Bills here… but the Broncos could come out on top on home with the holiday cheer in mind.
Record: 10-5.
Week 17: at Miami Dolphins, 1:00 p.m.
The Dolphins won’t be any better here.
Record: 11-5.
Week 18: vs. New York Jets, TBD.
Assuming the Bills have something to play for at home in their finale? A win.
Record: 12-5.
This article originally appeared on Bills Wire: Bills Wire game-by-game predictions for the 2026 NFL season
Reporting by Nick Wojton, USA TODAY / Bills Wire
USA TODAY Network via Reuters Connect
