Indianapolis Colts quarterback Daniel Jones (17) celebrates with wide receiver Alec Pierce (14) after Jones scores a touchdown during a game against the Arizona Cardinals on Sunday, Oct. 12, 2025, at Lucas Oil Stadium in Indianapolis
Indianapolis Colts quarterback Daniel Jones (17) celebrates with wide receiver Alec Pierce (14) after Jones scores a touchdown during a game against the Arizona Cardinals on Sunday, Oct. 12, 2025, at Lucas Oil Stadium in Indianapolis
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Instant analysis of Colts Week 6 performance vs. Cardinals

The Indianapolis Colts leave Week 6 with a 31-27 win over the Arizona Cardinals to improve to 5-1 on the season.

Let’s dive into our instant takeaways from the Colts’ performance.

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– The Colts have cruised to some easy wins this season, but this one tested them — and it’s good to have those challenges throughout a season, especially when you come out on top.

– The depth of the Colts’ cornerback room was tested. Already without Kenny Moore, Charvarius Ward was ruled out pre-game with a concussion. This left Mekhi Blackmon and Johnathan Edwards as the two outside starters. It looked like the Colts were trying to limit any downfield opportunities, which allowed Jacoby Brissett to find a lot of success underneath.

– The Colts’ run defense held up well, with the Cardinals averaging under 4.0 yards per run. However, as mentioned, the Arizona pass-catchers were able to get into space underneath, which set up YAC opportunities.

– PFF had the Colts’ defense with 29 pressures. However, they totaled just two sacks. With the ball coming out quickly, generating sacks becomes difficult.

– The Cardinals’ defense came into this game ranked fourth in points per game allowed. This was certainly the Colts’ toughest defensive test of the season. For a passing game that typically is very good at getting guys in space, that did not come easily in this game.

– Where the Colts’ offense did find success was in the run game, which gave them something to lean on. However, moving the ball solely on the ground is a tough way to live — it requires stringing together a lot of long drives in order to score.

– In his first game as the Colts’ kicker, Michael Badgley provided stability at the position.

– Nick Cross is flying under the radar around the NFL, but he’s playing some really good football this season.

– Short-handed on defense, we saw some unique alignments from Lou Anarumo, which included Ashton Dulin blitzing, Austin Ajiake at defensive end, and some other different defensive alignments.

– Our weekly Tyler Warren post — what a difference-maker he is for the Colts’ offense. Not only in the passing, but as a blocker and what he helps create for other pass-catchers with his versatility.

– This was the second game in a row where Josh Downs was featured heavily in the passing game after a quieter start to the season.

– As expected, Germaine Pratt was thrown into the mix right away at linebacker next to Zaire Franklin.

– Rigoberto Sanchez is such a weapon at punter.

– Third downs were a big difference in this game. The Cardinals were quite efficient while the Colts were not. The early down success for each team played a key role in determining those results.

– After two sloppy games with penalties, the Colts were much cleaner this week.

(Please note that this article will be updated.)

This article originally appeared on Colts Wire: Instant analysis of Colts Week 6 performance vs. Cardinals

Reporting by Paul Bretl, Colts Wire / Colts Wire

USA TODAY Network via Reuters Connect

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