Sep 6, 2025; Syracuse, New York, USA; Syracuse Orange quarterback Steve Angeli (9) throws against the UConn Huskies during the second half at JMA Wireless Dome. Mandatory Credit: Gregory Fisher-Imagn Images
Sep 6, 2025; Syracuse, New York, USA; Syracuse Orange quarterback Steve Angeli (9) throws against the UConn Huskies during the second half at JMA Wireless Dome. Mandatory Credit: Gregory Fisher-Imagn Images
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ESPN College GameDay picks who they think wins in Week 4 of college football

ESPN College GameDay is on location in Coral Gables, Florida as one of Notre Dame’s previous opponents, the Miami Hurricanes are hosting the Florida Gators.

It’s not the biggest game of the day, but it’s a huge rivalry game with the two teams going in different directions. The Hurricanes once again are looking like a College Football Playoff team, while the Gators haven struggled to a 1-2 record and there is chatter that the fan base wants head coach Billy Napier fired with eyes on the Irish’s Marcus Freeman.

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Regardless of that, the GameDay crew of Desmond Howard, Nick Saban, Pat McAfee and Kirk Herbstreit were joined by NHL star Matthew Tkachuk, son of great Keith, who’s Florida Panthers have won the last two Stanley Cups. They picked the top games across college football in Week 4, and you can find out below who they think will win.

Syracuse Orange at Clemson Tigers

Howard – Syracuse

Saban – Syracuse

Tkachuk – Syracuse

McAfee – Syracuse

Herbstreit – Clemson

South Carolina Gamecocks at No. 23 Missouri Tigers

Howard – South Carolina

Saban – Missouri

Tkachuk – Missouri

McAfee – South Carolina

Herbstreit – South Carolina

Kent State Golden Flashes at No. 7 Florida State Seminoles

Howard – Kent State (spread pick)

Saban – Florida State

Tkachuk – Florida State

McAfee – Florida State

Herbstreit – Florida State

No. 22 Auburn Tigers at No. 11 Oklahoma Sooners

Howard – Auburn

Saban – Oklahoma

Tkachuk – Oklahoma

McAfee – Oklahoma

Herbstreit – Oklahoma

SMU Mustangs at TCU Horned Frogs

Howard – TCU

Saban – TCU

Tkachuk – TCU

McAfee – TCU

Herbstreit – TCU

No. 9 Illinois Fighting Illini at No. 19 Indiana Hoosiers

Howard – Illinois

Saban – Illinois

Tkachuk – Illinois

McAfee – Indiana

Herbstreit – Illinois

No. 17 Texas Tech Red Raiders at No. 16 Utah Utes

Howard – Utah

Saban – Utah

Tkachuk – Utah

McAfee – Utah

Herbstreit – Utah

No. 21 Michigan Wolverines at Nebraska Cornhuskers

Howard – Michigan

Saban – Michigan

Tkachuk – Michigan

McAfee – Nebraska

Herbstreit – Michigan

Florida Gators at No. 4 Miami Hurricanes

Howard – Miami

Saban – Miami

Tkachuk – Miami

McAfee – Miami

Herbstreit – no pick

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This article originally appeared on Fighting Irish Wire: ESPN College GameDay picks who they think wins in Week 4 of college football

Reporting by Michael Chen , Fighting Irish Wire / Fighting Irish Wire

USA TODAY Network via Reuters Connect

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