The Miami Dolphins are slight road underdogs heading into their Week 1 matchup with the Indianapolis Colts. Last season, the teams met at Lucas Oil Stadium in Week 7, with the Colts coming away with a 16-10 win. However, several players were missing from last year’s game on both sides, but especially for the Dolphins.
Quarterback Tua Tagovailoa was out, as were edge rushers Bradley Chubb and Jaelan Phillips. Running back Jonathan Taylor did not play for the Colts. Anthony Richardson was the quarterback for the Colts, but it’ll be former New York Giants passer Daniel Jones under center for Indianapolis in Week 1.
Both teams added immediate impact players in the 2025 NFL draft with Miami’s No. 13 overall pick, defensive tackle Kenneth Grant. A pick later at No. 14 was tight end Tyler Warren for the Colts.
Here’s a look at the current betting odds and our prediction for the game:
Dolphins vs. Colts betting odds
Point spread: Dolphins +1.5 (-118)
Moneyline: Colts -112 | Dolphins -108
Point total: 47.5
Odds via DraftKings Sportsbook
Dolphins vs. Colts injury report
Dolphins
Colts
Dolphins vs. Colts score prediction
With Tua Tagovailoa in the lineup, the Dolphins have much more offensive firepower than they did in their 2024 loss in Indianapolis. Mike McDaniel is 3-0 in season openers and faces a Colts team that hasn’t won in Week 1 since 2013. Dolphins 20, Colts 17.
Dolphins 2025 remaining schedule
See more game predictions and betting picks at Sportsbook Wire.
This article originally appeared on Dolphins Wire: Dolphins vs. Colts betting preview: Spread, over/under, pick to win
Reporting by Jason Sarney, Dolphins Wire / Dolphins Wire
USA TODAY Network via Reuters Connect
