Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers offensive tackle Trent Williams (71) dances outside the locker room before player introductions against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images
Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers offensive tackle Trent Williams (71) dances outside the locker room before player introductions against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images
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49ers participation report from 2nd Week 2 practice has significant injury red flag

The San Francisco 49ers’ practice participation report from Thursday came with a significant red flag on the injury front.

As the injury problems stack up to include tight end George Kittle, quarterback Brock Purdy and wide receiver Jauan Jennings, another potential issue has sprouted up.

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Left tackle Trent Williams was listed as a non-participant in Wednesday’s session because of a knee injury, as well as his typical veteran rest day. He was once again a non-participant Thursday, bringing his availability for Week 2 into question.

Williams dealt with an injury in the 49ers’ Week 1 win over the Seattle Seahawks. He missed one snap and seemed to be laboring throughout the game. Pro Football Focus credited him with a team-worst six pressures allowed.

Head coach Kyle Shanahan on Wednesday didn’t indicate Williams was due to miss more than one day of practice. His absence Wednesday and Thursday doesn’t mean he won’t suit up Sunday, but it is notable that he isn’t practicing at all after suffering an injury in Week 1.

Spencer Burford would be the team’s starting left tackle if Williams can’t start Sunday in New Orleans. We’ll learn more about Williams’ status on the Friday injury report. Shanahan will also be available to give an update in a press conference after Friday’s practice.

Here’s the full Thursday practice report:

Did not participate

Purdy is almost certainly out for Sunday’s game. That Jennings has also not suited up for practice isn’t a great sign for his availability Sunday.

Limited participation

Good news for Gross-Matos here after he missed Wednesday’s practice. James and Watkins were inactive in Week 1. Watkins could play a real role in Week 2 if he’s back in action and Jennings isn’t available.

Full participation

It’s a great sign for McCaffrey that his calf issue isn’t hindering him after a game where he had 31 touches.

More 49ers: Former NFL gunslinger explains why injured 49er is “still underrated by most NFL fans”

This article originally appeared on Niners Wire: 49ers participation report from 2nd Week 2 practice has significant injury red flag

Reporting by Kyle Madson, Niners Wire / Niners Wire

USA TODAY Network via Reuters Connect

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