Oct 11, 2025; Tallahassee, Florida, USA; Florida State Seminoles wide receiver Micahi Danzy (19) after scoring a touchdown against the Pittsburgh Panthers in the fourth quarter at Doak S. Campbell Stadium. Mandatory Credit: Melina Myers-Imagn Images
Oct 11, 2025; Tallahassee, Florida, USA; Florida State Seminoles wide receiver Micahi Danzy (19) after scoring a touchdown against the Pittsburgh Panthers in the fourth quarter at Doak S. Campbell Stadium. Mandatory Credit: Melina Myers-Imagn Images
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FSU vs Wake Forest prediction, picks, odds: Who wins Week 10 college football game?

The Florida State Seminoles are set to play the Wake Forest Demon Deacons on Saturday as they look to snap their four-game losing streak and win their first ACC game of the season. FSU is 3-4 overall and is 5-14 over the past two seasons, with just one ACC win.

Wake Forest is 5-2 overall and 2-2 in conference play in Jake Dickert’s first season in charge. They beat the SMU Mustangs 13-12 on Saturday for their third straight win. They are 2-0 on the road this season, with wins at Virginia Tech and Oregon State.

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They are averaging 26.7 points per game, which is 11th in the ACC, and allowing 18.9 points, which is second. Their 394.3 yards per game is the 11th most in the conference. FSU leads the conference in yards per game (523.3), is second in points per game (39.7), and ninth in points allowed (22.6)

Stream FSU vs Wake Forest

This is the first time that FSU and Wake Forest have played since 2023, when the Seminoles won 41-16 on the road. FSU leads the series 31-9-1 and is 20-4-1 in Tallahassee, but Wake Forest did win the most recent meeting in Doak Campbell Stadium in 2022.

Here is an early look at the betting odds and a prediction for Saturday’s game between FSU and Wake Forest.

FSU vs Wake Forest odds, money line, over/under

Odds courtesy of BetMGM as of Monday, Oct. 27

FSU vs Wake Forest predictions, picks for college football Week 10

JD McCarthy

Wake Forest 24, FSU 20: While this is a game FSU has to win to have any chance of salvaging their season, they have not looked like a winning team for quite some time. They are more talented than Wake Forest, but the Demon Deacons have found a way to win this year, and they will keep it going on Saturday, handing FSU their fifth straight loss.

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This article originally appeared on FSU Wire: FSU vs Wake Forest prediction, picks, odds: Who wins Week 10 college football game?

Reporting by JD McCarthy, FSU Wire / FSU Wire

USA TODAY Network via Reuters Connect

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