Iowa State football continues its 2025 season on Saturday, Nov. 22, with a Big 12 Conference home game against Kansas.
The Cyclones (6-4, 3-4 Big 12) are coming off their third and final bye week, hoping to build on their Week 11 20-17 win at TCU.
The Jayhawks (5-5, 3-4) are coming off a 24-20 loss at Arizona.
Here are some predictions and the betting lines for the game:
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Iowa State vs. Kansas odds, moneyline, over/under
Odds courtesy of BetMGM as of Friday evening.
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Iowa State vs. Kansas predictions, picks for college football Week 13
Des Moines Register columnist Travis Hines: “The Cyclones’ offense didn’t show any signs of improvement the last time out against TCU, but their running game, combined with Kansas’ inability to stop the run, should be enough to get it done at home. Iowa State 17, Kansas 14.” – (full prediction column)
This article originally appeared on Des Moines Register: Iowa State vs Kansas predictions, picks, odds college football Week 13
Reporting by Gus Martin, Des Moines Register / Des Moines Register
USA TODAY Network via Reuters Connect
