No. 21 Iowa State football continues its 2025 season on Saturday, Oct. 11, with a Big 12 Conference road game against Deion Sanders’ Colorado Buffaloes.
The Cyclones (5-1, 2-1 Big 12) are coming off a disappointing 38-30 loss at Cincinnati.
The Buffaloes (2-4, 0-3) are on a two-game losing streak, most recently falling 35-21 at TCU.
Here are some predictions and the betting lines for the game:
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Iowa State vs. Colorado odds, moneyline, over/under
Odds courtesy of BetMGM as of Friday evening.
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Iowa State vs. Colorado predictions, picks for college football Week 7
Travis Hines, Iowa State columnist: “The lack of a real kicking game is scary for Iowa State, but giving Becht four downs to make 10 yards once the Cyclones cross the 50 should mean some touchdowns on the board for the Cyclones. Iowa State 28, Colorado 27.” – (full prediction column)
This article originally appeared on Des Moines Register: Iowa State vs Colorado predictions, picks, odds, who wins Week 7 college football game?
Reporting by Gus Martin, Des Moines Register / Des Moines Register
USA TODAY Network via Reuters Connect
