Nov 15, 2025; Pittsburgh, Pennsylvania, USA; Notre Dame Fighting Irish head coach Marcus Freeman reacts after an Irish touchdown against the Pittsburgh Panthers during the second quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images
Nov 15, 2025; Pittsburgh, Pennsylvania, USA; Notre Dame Fighting Irish head coach Marcus Freeman reacts after an Irish touchdown against the Pittsburgh Panthers during the second quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images
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'Cuse-Notre Dame predictions, picks, odds: Who wins Week 13 CFB game?

The US LBM Coaches Poll No. 9 Notre Dame hosts Syracuse on Saturday in South Bend this afternoon, and its looking to not do anything disastrous to ruin what appears to be a safe bid into the College Football Playoff.

The Fighting Irish have won eight-straight games and are looking like they’re peaking at the right moment. It’s the eye test that pushed Notre Dame back in the top-12 and a potential challenger to win the national title.

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Below you’ll find what the current odds are along with a quick prediction of how Notre Dame’s Senior Day will turn out against Syracuse.

Peacock: https://imp.i305175.net/Y9vDoJ

Syracuse vs. Notre Dame odds, money line, over/under

Odds courtesy of BetMGM as of Saturday, November 21

Syracuse vs. Notre Dame predictions, picks for college football Week 13

Dave Miller

Notre Dame 44, Syracuse 16: It may be a rough day for Orange freshman QB Joe Filardi, who could get humbled against this Fighting Irish defense. The former walk-on will be making his first start on the road against a Marcus Freeman-led squad that likely understands style points matter as it relates to Miami.

Enjoy the weekend before Thanksgiving, Irish fans.

This article originally appeared on Fighting Irish Wire: ‘Cuse-Notre Dame predictions, picks, odds: Who wins Week 13 CFB game?

Reporting by Dave Miller, Fighting Irish Wire / Fighting Irish Wire

USA TODAY Network via Reuters Connect

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