San Francisco 49ers quarterback Brock Purdy (13) scrambles out of the pocket against the Arizona Cardinals at State Farm Stadium in Glendale on Nov. 16, 2025.
San Francisco 49ers quarterback Brock Purdy (13) scrambles out of the pocket against the Arizona Cardinals at State Farm Stadium in Glendale on Nov. 16, 2025.
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49ers-Panthers: Who do experts think will win SF's Week 12 game?

After beating the Arizona Cardinals 41-22 last Sunday on the road, the San Francisco 49ers have returned home and will take on the Carolina Panthers on Monday night at Levi’s Stadium in Week 12.

San Francisco got quarterback Brock Purdy and wide receiver Ricky Pearsall back last week, and with a full week of practice, they should be even better on Monday. Now, they’re hoping to end the streak of winning every other week and start a winning streak.

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Carolina has done the same over the last five weeks, beating the Jets, losing to the Bills, beating the Panthers, losing to the Saints and beating the Falcons. Former first-round pick Bryce Young and 2025 first-round pick Tetairoa McMillan could challenge San Francisco’s injury-riddled defense and make this a contest even though it shouldn’t be.

Before these two teams meet on the field on Monday night, we’ve gone through picks from roughly 40 experts from different sites/publications to see who they’re taking in this matchup. Let’s take a look at what they said.

Here are all the top expert picks for 49ers vs. Panthers in Week 12:

USA Today Sports

ESPN

CBS Sports

Sports Illustrated

Bleacher Report

NFL.com

More 49ers: 49ers officially downgrade edge rusher to OUT vs. Panthers on MNF

This article originally appeared on Niners Wire: 49ers-Panthers: Who do experts think will win SF’s Week 12 game?

Reporting by Mike Masala, Niners Wire / Niners Wire

USA TODAY Network via Reuters Connect

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